Beilstein J. Nanotechnol.2015,6, 254–262, doi:10.3762/bjnano.6.24
biomedical applications for tissue engineering due to their morphological resemblance to the extracellular matrix (ECM). Especially, there is a need for the cardiovascularimplants to exhibit a nanostructured surface that mimics the native endothelium in order to promote endothelialization and to reduce the
complications of thrombosis and implant failure. Thus, we herein fabricated poly-ε-caprolactone (PCL) electrospun nanofibrous scaffolds, to serve as coatings for cardiovascularimplants and guide tissue regeneration. Oxygen plasma treatment was applied in order to modify the surface chemistry of the scaffold
of these biomimetic tissue-engineering constructs as efficient coatings for enhanced compatibility of cardiovascularimplants.
Keywords: cardiovascularimplants; electrospun nanofibers; plasma treatment; scaffold; tissue engineering; Introduction
Cardiovascular diseases represent one of the major
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Figure 1:
SEM and AFM images of the (a,d) untreated PCL electrospun scaffolds and of the O2-plasma modified o...